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first_imgNagaland Director General of Police (DGP) Rupin Sharma has initiated a move to shut moneylenders out of the department.In an order on Wednesday, Mr. Sharma set up a seven-member committee for exploring the possibility of providing short-term loans to police personnel from the Nagaland Police Risk Insurance Scheme (NPRIS).This was primarily to dissuade constables, officers of lower ranks and other staff from taking loans from private moneylenders.“From interactions with police personnel across all units of Nagaland police, we came to know that taking loans from private moneylenders at exorbitant interest rates of up to 25% has become a habit for many,” Mr. Sharma said.It was also learnt that unit commanders and drawing and disbursing offers had sometimes been deducting the principal amount and interest money in cash before demitting the salaries to the bank accounts of the police personnel, his order said.“The degree of financial literacy was not up to the mark and this has created not only financial problems but also fostered other ills in the management of the force,” the order said. The Nagaland police department had about 26,000 employees. Each employee contributed a specific amount – currently ₹150 – every month to NPRIS. The monthly deposit in the scheme from regular contributors works out to an average ₹24,500.“The short-term loan mechanism was being worked out since NPRIS has a system of payouts on retirement or death. This is just the beginning of the process with detailed recommendations expected soon,” Mr. Sharma told The Hindu.The committee headed by ADG (law and order) Renchamo P Kikon has been asked to submit report by April 25.last_img read more

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first_imgFour children were injured when a mobile phone battery exploded at Lunguri village in Ganjam district of Odisha on Monday. According to police sources, the children were playing with a discarded mobile phone battery when the blast occurred. The injured children were between 10 and 12 years. Luckily none of them received lethal injury in the blast, the sources said. One of the children had found a discarded phone battery and they were trying to connect it to an LED bulb when it exploded. Another incidentIn a similar incident, a 13-year-old student of Class VIII was injured on Monday at Kalimatu village of Nupada district when the battery of a mobile phone exploded. The incident happened when the boy was charging the phone. His right eye was completely damaged.On March 17, a girl named Uma Oram (18) of Kheriakani village of Jharsuguda district died when the battery of her cell phone exploded while she was talking. The mobile phone was connected to the charger at the time of the incident.last_img read more

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first_imgA doctor-turned-model-turned-actor and her cook were taken into preventive custody after a scuffle broke out between the two, the police said on Friday. However, hundreds of domestic workers held a protest under the banner of Gharelu Kamgar Union accusing the police of high-handedness and sought the Deputy Commissioner’s intervention.According to Maya Das, who works as a cook at the house of Tina Chatwal, 38, a former Miss Asia Pacific, her employer was angry when she did not find the meal cooked to her liking and began to beat her up. Ms. Chatwal allegedly grabbed her by hair, kicked her in the stomach, and slapped her several times. She was later taken to Paras Hospital.SHO, Sector 53, Arvind Dahiya said both the help and her employer claimed to have been roughed up by each other. “We had a complaint from the help and a counter-complaint from her employer. Both had got their medical examination done and procured the Medico-Legal Certificate. So both were taken into preventive custody and produced before the Deputy Commissioner of Police, Headquarters,” said Mr. Dahiya. The two were later let off. But Maya John of GKU alleged in a letter to Deputy Commissioner Vinay Pratap Singh that the police were favouring the employer. She pointed out in her letter that the injuries to the help were visible and undeniable and prior to taking the help into custody “the police did not collect the CCTV footage of the accused’s apartment” complex which shows the employer brutally beating up the domestic worker”.last_img read more

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first_img The phase 1 involves building a 77 m-tall and a 2 km-wide dam, the Dhaudhan dam, and a 230 km canal to transfer extra water from the Ken river for irrigating 3.64 lakh hectares in the Bundelkhand region of Uttar Pradesh and Madhya Pradesh.Originally, this phase envisaged irrigating 6,35,661 ha (hectares) annually (3,69,881 ha in M.P. and 2,65,780 ha in U.P.). In addition, the project was to provide 49 million cubic metres (MCM) of water for en route drinking water supply.No longer validWhile there’s a 2005 agreement between the two States on how water would be shared, Madhya Pradesh said last year that these assumptions were no longer valid and the only way to meet increased water requirements would be to include certain local water management projects — the Kotha barrage, Lower Orr and Bina complex that were envisaged in the second phase of the project — in the first phase.In theory, this could mean a completely fresh environmental appraisal. The Central Water Commission is yet to officially take a call, though government sources say the Centre is agreeable to the change. However, new demands by Madhya Pradesh for more water during the Rabi season are yet to be negotiated. Disagreements over water-sharing and difficulty in acquiring non-forest land impede the ₹18,000-crore Ken Betwa river interlink project.The scheme, which involves deforesting a portion of the Panna Tiger Reserve in Madhya Pradesh, was accorded clearance by the National Wildlife Board on the condition that the land lost would be made good by acquiring contiguous, revenue land. This is to ensure that wildlife corridors in the region aren’t hit. “The M.P. government has said that they are facing major difficulties over this,” said a senior person in the Water Ministry involved with the project.Unlikely this yearAnother hurdle is a dispute over how Uttar Pradesh and Madhya Pradesh — the two beneficiaries — will share water in the Rabi season.These “major” issues made it quite unlikely that the project will get under way this year. A person familiar with the deliberations told The Hindu, “New points of differences between the two States are constantly being raked up…there are still many things to be ironed out before the project can be sent for the [Union] Cabinet’s approval.”Conceived as a two-part project, this is the country’s first river interlinking project. It is perceived as a model plan for similar interstate river transfer missions.last_img read more

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first_imgAccused Sunil Kumar arrested in connection with the rape and murder of a three-year-old girl earlier this month had abducted and killed seven more girls — aged between 3 to 8 years — after raping them in separate cases in Gurugram, Delhi and Madhya Pradesh over the past two years, the police said on Tuesday.Of the seven victims, two are from Gurugram, three from Delhi and one each from Gwalior and Jhansi, said DCP (Crime) Sumit Kuhar.From religious placesThe 20-year-old Sunil would abduct minor girls from near bhandaras (community feasts) at religious places. Then he would rape and later kill them, the police said. He would also abduct minor girls from slums when their parents would be away for work.Mr. Kuhar said the accused would brutalise his victims — break their limbs — before killing them.Sunil had confessed to the murders during interrogation and the facts were being verified from the police stations concerned, the officer said.Besides the rape and murder of the three-year-old, abducted from a slum cluster in Sector 66 on November 11, Sunil had kidnapped a girl from outside a temple on Sohna Road in November 2016 and another girl at Civil Lines in January last. Both the girls were raped and murdered.In the present case, the victim was subjected to brutality during rape causing severe injuries to her private parts. She was hit with a heavy object and died due to head injuries. Mr. Kuhar said the police have questioned around 2,000 vagabonds sleeping on the roads during an extensive search operation for the accused. “We had information that he preferred to eat at community feasts at religious places and slept on the roads. We conducted three community feasts on November 13, 22 and 24 laying a trap for him,” said Mr. Kuhar.Sunil ate at a gurudwara and spent the night at Nehru Park after the commission of crime on November 11. He then reached Delhi and took a train to Uttar Pradesh on the next day after spending the night under Nizamuddin bridge.The senior police officer said on the earlier two occasions, the police had no clue but this time around he was seen luring the victim. He was also captured on a CCTV camera at a group housing society along with his victim and his relatives also provided his picture.The accused is from UP’s Mahoba district. He was nabbed from at UP’s Magapur village on Monday. Sunil was produced before the court in the afternoon and remanded in eight days police custody, the police said.last_img read more

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first_imgIt takes a lot to deter a male from wanting sex. A new study has found that male mice keep trying to copulate even when they are in pain, whereas females engage in less sex. But when given drugs that target pleasure centers in the human brain, the females again became interested. The findings could shed light on the nature of libido across various animal species.To assess how pain influences sexual desire, researchers first identified pairs of mice that wanted to have sex. “What we found early on was not all mice will mate with each other,” says clinical psychologist Melissa Farmer, who led the study while earning her Ph.D. at McGill University in Montreal, Canada. The team set up the rodents on a series of “dates,” during which a male and female were paired together for 30 minutes. Couples that copulated for most of the session were deemed compatible and moved into a cage with separate rooms. A small doorway allowed a female mouse to freely cross over from her chamber, but the male—which is larger—could not.The scientists then induced pain in males or females by applying a small dose of inflammatory compounds to the cheek, tail, foot, or genitals. The sensation would primarily be soreness, like a bad sunburn, says Farmer, who now works at Northwestern University’s Feinberg School of Medicine in Chicago, Illinois.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Female mice that were in pain, whether genital or nongenital, spent 50% less time with their male partners, implying a decrease in sexual motivation. Even when they did visit their paramours, females wouldn’t allow males to mount them with the same frequency, the team reports online today in The Journal of Neuroscience.The researchers then set up the reverse scenario in which males dictated the encounters. They placed both mice in an “open-field” cage with no barriers. Males desired just as much sex even if they were in pain, and the researchers observed no significant difference in mounting attempts or other sexual behaviors.Pain-relieving drugs increased females’ willingness to mate, and two sex-drive enhancers—apomorphine and melanotan II—did the same. Both drugs tweak neural circuits tied to pleasure and arousal.Women exercise more caution when selecting a mate, which many psychologists attribute to cultural expectations, such as when female modesty is pushed by some religions. In other words, social norms might impose female repression of sexual desire. In contrast, Farmer and her colleagues conclude, somewhat controversially, that women might simply be more biologically prone to sexual repression in certain contexts.Jill Becker, a behavioral neuroscientist at the University of Michigan, Ann Arbor, supports the idea. “It’s valid given the amount of female investment [in reproduction] and the way that these systems must have evolved to ensure reproductive success.”Yet other researchers hesitate to build such a major bridge between mice and man. “Claiming an evolutionary basis to sexual behavior based on one study trivializes the rich complexity of human behavior,” says Barry Komisaruk, a behavioral neuroscientist at Rutgers University, Newark, in New Jersey. “It implies inevitability to a woman’s behavior—that she has no voluntary control. That’s too much to extrapolate from one mouse study.”last_img read more

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first_imgAs red blood cells zip through vessels, they deliver oxygen to nearly every nook and cranny of your body. But oxygen isn’t all they can tote around. By engineering red blood cells to have “sticky” proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.“This is really a great idea, and a very novel approach,” says biochemist Vladimir Muzykantov of the University of Pennsylvania, who was not involved in the new work.Red blood cells account for a quarter of all human cells in the body and survive for an average of 4 months. Their ubiquity and long life makes them an ideal vehicle to carry therapeutics throughout the body, says immunologist Hidde Ploegh of the Massachusetts Institute of Technology in Cambridge. Previously, researchers have loaded red blood cells with drugs by pushing the molecules through the cell’s membrane into its interior, but the process weakens the cell, and the molecules are released only when the cell reaches its final destination.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Ploegh and his colleagues instead wanted to attach molecules to the outside of red blood cells. Because red blood cells don’t have nuclei—and therefore lack genetic material that can be tweaked to make new proteins—the researchers turned to erythroblasts, precursors to red blood cells that still contain DNA. The scientists added to erythroblasts altered versions of genes that are known to encode proteins found on the surface of red blood cells. The introduced gene sequences, though, had modifications so that the erythroblasts produced surface proteins with an extra marker that’s recognized by a protein called sortase.Those engineered proteins remained as the erythroblasts matured into red blood cells. When the researchers added sortase to the matured cell mixtures, the protein snipped off the ends of any proteins the researchers had genetically modified, leaving “sticky” trailer hitches for cargo. Any molecule with a corresponding sortase tag would then bind to the surface protein on the red blood cell. To show that the hitch would work, Ploegh’s team attached the vitamin biotin to red blood cells and infused them into mice. The biotin-toting cells survived for at least 28 days in circulation and did not harm the mice, they report online today in the Proceedings of the National Academy of Sciences.Ploegh envisions the technique being used to create a new type of personalized therapy in the future—your own cells could be isolated, used to create stem cells that differentiate into erythroblasts, genetically modified to carry a molecule, and reinjected into your body. Any molecule that needs to be spread through the circulatory system could be the cargo. By the time the cells have matured back into red blood cells, they will have lost their DNA, eliminating the risk of ongoing mutations or the spread of genetic materials. “The payloads you can install are limitless,” Ploegh says. “But a lot of the applications are still, for now, hypothetical.”Muzykantov, who has developed other approaches for using red blood cells as molecular vehicles, says the significance of the new method “exceeds just drug delivery.” It could be used to track red blood cells to diagnose blood diseases, spread imaging agents throughout the body to visualize atherosclerotic plaques or blocked arteries, or neutralize the immune system before transplants by blocking antibodies that enter the bloodstream.“But there are lots of questions to address in animal models,” he adds. “I would love to see a demonstration that a real drug binds to a red blood cell using this approach and is still effective.”last_img read more

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first_imgWhat is the meaning of water clouds detected just 7 light-years from Earth? What can walking fish tell us about how the first animals adapted to land? And why are humans so nice to each other? Science’s Online News Editor David Grimm chats about these stories and more with Science’s Sarah Crespi.last_img

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first_imgGut surgery is often the only option for life-threatening obesity and diabetes, but what if doctors could cut the pounds without using a knife? Scientists have engineered an antiobesity drug that rivals the dramatic benefits seen with surgery, dropping excess body weight by a third. Though the work was done only in rodents, the drug is the first to influence three obesity-related hormones in the gut at once.Bariatric surgery, including gastric bypass, typically involves limiting food intake by removing part of the stomach or intestines. Yet it does more than shrink the size of patient’s stomach or intestines. It also changes the release of multiple gut-related hormones, explains clinical endocrinologist Stephen O’Rahilly of the University of Cambridge in the United Kingdom, who wasn’t involved with the study. That’s important, because years of eating a diet high in fat and sugar can throw a person’s metabolism into disarray. Cells undergo genetic reprogramming that negatively impacts how they process sugar and store fat, locking in obesity. This pattern makes it harder and harder to lose weight, even if a person changes their diet and begins exercising.Bariatric surgery interrupts that cycle by stimulating the production of several hormones that reduce blood sugar, burn fat, and curb appetite. (It may also change the composition of the gut’s microbes.) Three of these hormones are called glucagon-like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), and glucagon. Cells in your gut release GLP-1 and GIP after a meal to keep your body’s blood sugar levels in a normal range. GLP-1 also curbs appetite, signaling to your brain that you are full. In type 2 diabetes, the body stops responding to GLP-1 and GIP, which contributes to hyperglycemia, or too much blood sugar. Hyperglycemia causes the devastating hallmarks of diabetes, such as kidney injury, cardiovascular disease, and nerve damage.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Glucagon, in contrast, causes blood sugar levels to rise by telling the liver to convert fat into sugar. As hyperglycemia progresses in diabetes, the body shuts the hormone off in a presumed attempt to restore sugar balance, but that also stymies fat burning. In normal people and bariatric surgery patients, glucagon lowers fat and can trigger weight loss.Existing medications can individually boost the levels of each of these hormones, but the drugs have a limited effect on obesity and diabetes. For instance, GLP-1 drugs only shave off an average of about 2.7 kilograms in human trials and also have unfortunate side effects like severe nausea and vomiting. These challenges have convinced many researchers that “the way forward with obesity drug therapy is hitting more than one gut hormone at once,” O’Rahilly says.So that’s what endocrinologist Matthias Tschöp, research director of the Helmholtz Diabetes Center in Munich, Germany, and colleagues set out to do. They engineered a protein that takes structural pieces of GLP-1, GIP, and glucagon and merges them into a single molecule. To create the hybrid, the team started with an engineered protein that combined GLP-1 and glucagon, then spent years making small changes to add GIP components. Each time a tweak was made, the researchers would test the hybrid hormone in cells or mice to see if it still stimulated each hormone pathway. By the end, they had a drug packed with the power to turn on glucagon, GLP-1 and GIP signals, but not other hormone systems—an unprecedented feat for obesity drug design.When given to obese and diabetic rodents, the drug triggered metabolic changes—glucose lowering, fat burning, and weight loss—to the same degree that bariatric surgery had in previous studies. The compound caused the rodents’ body weight to drop by a third, on average, over 3 weeks and cut their blood glucose in half. It also reduced fat mass by a third, while keeping healthy lean mass intact, Tschöp and his colleagues report online today in Nature Medicine.“Think of this as an injectable elixir that could reverse obesity and type 2 diabetes by cheating a body into believing that it just received a gastric bypass,”  Tschöp says. That means a commercial drug based on this research could potentially confer the benefits of bariatric surgery without the risks of a physical operation.The project required some remarkably clever chemistry and is one of the more thorough evaluations of a drug for obesity and diabetes, O’Rahilly says, though he points out that true test will come in humans. ”In the end, you don’t throw a party until you have a drug that works in people.”last_img read more

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first_imgResearchers have increased the size of mouse brains by giving the rodents a piece of human DNA that controls gene activity. The work provides some of the strongest genetic evidence yet for how the human intellect surpassed those of all other apes.”[The DNA] could easily be a huge component in how the human brain expanded,” says Mary Ann Raghanti, a biological anthropologist at Kent State University in Ohio, who was not involved with the work. “It opens up a whole world of possibilities about brain evolution.”For centuries, biologists have wondered what made humans human. Once the human and chimp genomes were deciphered about a decade ago, they realized they could now begin to pinpoint the molecular underpinnings of our big brain, bipedalism, varied diet, and other traits that have made our species so successful. By 2008, almost two dozen computerized comparisons of human and ape genomes had come up with hundreds of pieces of DNA that might be important. But rarely have researchers taken the next steps to try to prove that a piece of DNA really made a difference in human evolution. “You could imagine [their roles], but they were just sort of ‘just so’ stories,” says Greg Wray, an evolutionary biologist at Duke University in Durham, North Carolina.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Wray is particularly interested in DNA segments called enhancers, which control the activity of genes nearby. He and Duke graduate student Lomax Boyd scanned the genomic databases and combed the scientific literature for enhancers that were different between humans and chimps and that were near genes that play a role in the brain. Out of more than 100 candidates, they and Duke developmental neurobiologist Debra Silver tested a half-dozen. They first inserted each enhancer into embryonic mice to learn whether it really did turn genes on. Then for HARE5, the most active enhancer in an area of the brain called the cortex, they made minigenes containing either the chimp or human version of the enhancer linked to a “reporter” gene that caused the developing mouse embryo to turn blue wherever the enhancer turned the gene on. Embryos’ developing brains turned blue sooner and over a broader expanse if they carried the human version of the enhancer, Silver, Wray, and their colleagues report online today in Current Biology.The researchers determined that HARE5 likely controls a gene called Frizzled 8, which is part of a molecular pathway important in brain development. Their further studies showed that the human version of the enhancer causes cells that are destined to become nerve cells to divide more frequently, thereby providing a larger of pool of cells that become part of the cortex. As a result, the embryos carrying human HARE5 have brains that are 12% larger than the brains of mice carrying the chimp version of the enhancer. Silver and Wray plan to test these mice to see if the bigger brains made them any smarter.”They have found a smoking gun in the human genome that connects a regulatory element with a proposed pathway for increasing brain size,” says Todd Preuss, a neuroanatomist at the Yerkes National Primate Research Center in Atlanta, who was not involved with the work.But he; geneticist Evan Eichler of the University of Washington, Seattle; and others point out that there’s more to be done. Several researchers worry that more extensive studies are needed to nail down that the HARE5 effects are not by chance. They’d like to see Silver and her colleagues replace the mouse HARE5 with the human and chimp HARE5—a feat the Duke group has yet to succeed in doing.Even so, Eichler is pleased with just how much the Duke team has learned so far. And, Wray says, given the growing ability of researchers to study enhancers and other DNA in mice, “my guess is there are probably other stories like this in the works.”last_img read more

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first_imgWhat brought Indians to the United States, and what made Indian immigrants, as a whole, so successful once here? Related Itemslast_img

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first_imgThe Hard Rock Hotel & Casino in Punta Cana, Dominican Republic, has a “Hindu” pizza on its menu containing “chicken tikka masala with yogurt, cilantro and mint,” and this has upset some Hindus.In a statement, Hindu statesman Rajan Zed, President of the Universal Society of Hinduism, termed it as a trivialization of the oldest and third largest religion of the world with about 1.1 billion adherents and a rich philosophical thought.Read it at NewsIndiaTimes Related Itemslast_img read more

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first_imgIn my cultural world, two major events defined the beginning of the year 2009 — the Obama inaugural and the movie Slumdog Millionaire.Both events are meaningfully connected in the popular culture. There is a synergy between the improbable victory of Obama in the presidential elections and the Hollywood/Bollywood rags to riches caper that went on to win the Oscar for the best picture of the year. Barack Obama, a half-Kenyan American, from Hawaii via Indonesia and Chicago has taken on the mantle of the first African American and the first global president of the United StatesBoth stories are about outsiders who come from the fringes of society yet manage to prevail against all the odds. Obama, a half-Kenyan American, from Hawaii via Indonesia and Chicago, has taken on the mantle of the first African American and the first global president of the United States.The key protagonist in Slumdog Millionaire is a young man, named Jamal, an orphan Muslim minority from one of the poorest slums in Mumbai, India. He not only manages to get on the popular game show, Who wants to be a Millionaire, but to the dismay of the game show host and the local police authorities, is able to correctly answer all the questions to take home the coveted prize.Both narratives are also about the power of globalization. Obama’s win represents the triumph of the American brand of multiculturalism at home and abroad, won on the backs of the hard-fought victories of the civil rights movement and the emerging post-racial world.Slumdog Millionaire represents the flush of new capital pouring into big metro areas like Mumbai, extolling the virtues of American greed and the free market economy, over the two thousand years old Hindu work-ethic encapsulated in the Bhagavad Gita, which professes that one should perform one’s duties (dharma) as self-less action (karma) and not to be motivated by the fruits of one’s labor or profits.To the disappointment of many educated and diaspora Indians, who are part and parcel of the emerging “incredible India,” it is clear that old stereotypes are hard to change. In the movie, India continues to be depicted as “a vast public latrine,” as V. S. Naipaul said in An Area of Darkness almost 50 years earlier, but at least now it’s part of the back office of American corporations and other multinational firms.Finally, both Obama and Slumdog represent a wave of populism that surfaces in hard economic times. Notwithstanding the hard-boiled film-making of Danny Boyle, the English/Irish director well-known for making gritty films about the downtrodden, the story of the orphan slum dwellers touches American hearts, because the global economy is in an abysmal dump. Thus, a brutal yet beautiful film makes us appreciate how blessed we really are as Americans and how good we really have it. The key protagonist in Slumdog Millionaire, named Jamal, an orphan Muslim minority from one of the poorest slums in Mumbai, not only manages to get on the popular game show Who wants to be a Millionaire, but to the dismay of the gameshow  host and the local police authorities takes home the coveted prize.Observing the populist elation at the Obama victory, Frank Rich wrote in the New York Times, “We’ll soon remember that the country is in a deep ditch, and that we turned to the black guy not only because we hoped he would lift us up, but because he looked like the strongest leader to dig us out.”However, populism can easily turn into rage against its chosen heroes. The actors in Slumdog Millionaire learned this when they returned home from the Oscars to angry mobs of slum dwellers who were upset at being depicted as a colony of sub-human species. Recently, the Obama dawg millionaires have not been spared the populist outrage either at their perceived lack of connection with the American people over the banking crisis and the dolling out of whopping AIG bonuses.And therein may be the perils for Obama as well. Related Itemslast_img read more

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first_imgFor the first time, the Jammu and Kashmir government has ordered stopping of traffic on the 97-km national highway and halting train services in south Kashmir during daytime till the 45-day Amarnath Yatra concludes in the State, evoking sharp reactions.According to an official handout of the Railways, no train will be available between 10 a.m. and 3 p.m. from Qazigund to Banihal. “Before 10 a.m. and after 3 p.m., trains will be available between Baramulla and Banihal. After completion of the yatra, trains will be available all day,” the spokesman said.In a separate order, the government directed that no civilian traffic will be allowed on the Srinagar-Jammu national highway from Qazigund to Nashri from 10 a.m. up to 3 p.m during the yatra period. Cut-off timeIn the past, authorities used to set a cut-off time for the vehicles carrying pilgrims from outside the State to reach the twin base camps in south and central Kashmir.The unprecedented move has evoked sharp reactions from the civil society and political parties.A spokesman of the Fruit Growers’ and Dealers’ Association said, “It will cause extreme hardship for those transporting fresh fruits, particularly cherry and plum, which are perishable items. The apple crop stored in cold storages will also get damaged.”The association requested the Governor’s administration “to consider revocation of the orders”.A delegation of the Kashmir Chamber of Commerce and Industry (KCCI) met Divisional Commissioner Baseer Ahmad Khan to discuss the issue. “Tourists and persons associated with the tourism sector will face difficulties,” said KCCI member Nasir Hamid Khan.J&K People’s Movement chairman Shah Faesal said the pilgrims were welcome to the “land of Shiva but the suspension of the train services must end”.“In the past 30 years, it’s for first time that the national highway was closed for civilian movement. This curfew must end,” he said.People’s Conference spokesman Adnan Ashraf said the decision was “unjustified”. “Disrupting the lives of local people and tourists on the pretext of paving a safe way for the yatris would send a wrong signal to the people of Kashmir,” he said.State Congress president G.A. Mir termed the move as “bizarre”. “It should be revoked to ensure that people and tourists are not put to hardship,” he said.Meanwhile, a new batch of 4,600 pilgrims left Jammu for Kashmir on Wednesday to perform the yatra. Till date, 11,456 pilgrims have paid their obeisance at the cave this year, officials said.last_img read more

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first_imgUnknown gunmen killed the personal security officer of Peoples Democratic Party (PDP) leader Sajad Mufti outside a mosque after Friday prayers in the Bijbehara area of Anantnag.“Policeman Farooq Ahmad Reshi sustained critical gunshot injuries. He was evacuated to hospital for medical treatment. However, he succumbed to his injuries,” the police said.Mr. Mufti was inside the mosque when the gunmen struck outside and snatched the service rifle from the constable, police officials said.The attack came just six days after National Conference (NC) leader Peer Tauqeer Shah’s guard was killed in an attack in the Kokernag area of Anantnag.Heavy pricePDP president Mehbooba Mufti, a close relative of Mr. Mufti, said, “Such dastardly acts only add to the woes of the masses. Either ways, Kashmiris are paying a heavy price.”Several parties have condemned the attack.NC’s view“Another police bodyguard killed in the line of duty in south Kashmir. I condemn the attack,” National Conference vice-president Omar Abdullah said.The Congress, in a statement, demanded that the authorities “ascertain the identity of the killers for severe punishment”.The Jammu and Kashmir Pradesh Congress Committee described the incident as a “mindless and shameful act on the part of killers”.“Violence in any form and manifestation is condemnable. Such incidents are inhuman and unfortunate and the perpetrators of violence have achieved nothing except for rendering irreparable loss to the victim family,” Mohammad Yousuf Tarigami, Communist Party of India (Marxist) leader, said.last_img read more

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first_imgA proposal for establishment of the Odisha Maritime Board for administration, control and management of non-major ports and non-nationalised inland waterways was approved by the State Cabinet here on Friday.The Cabinet meeting, presided over by Chief Minister Naveen Patnaik, decided that the Board will function as a single window facilitator for the overall maritime development of the State.Earlier a Bill was passed in 2011 for constitution of the Board but was withdrawn because some more issues were to be added, according to official sources.Odisha is endowed with a vast coastline of 480 km, having rich, unique and natural port locations and perennial rivers.14 non-major portsOut of the 14 sites identified for development of 14 non-major ports, two at Gopalpur and Dhamra are operational and two at Astarang and Subarnarekha are in the pipeline.According to the proposal, the Board will provide policy, guidelines and directions for the integrated development of ports and inland water transport keeping in view of the country’s security and defence related concerns.The salient features of the Board will be to provide construction, maintenance and operation of all non-major ports in the State directly or through PPP mode.The Board will be constituted with 12 members, the Chief Secretary as the chairperson along with representatives of stakeholders departments as well as representatives of the Central government.Among other proposals, the Cabinet also gave its approval for financial restructuring of the Odisha State Road Transport Corporation by which old dues of the Corporation and the State government will be settled forever.OSRTC’s lossesAs per the decision, OSRTC’s accumulated losses of ₹189.99 crore will be taken up against the share capital in a phased manner. Once the losses are adjusted, the OSRTC will have the option to approach the financial institutions for taking up commercially viable projects for better passenger amenities.last_img read more

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first_imgTaking serious note of the six killings in Allahabad, the U.P. government on Monday suspended Senior Superintendent of Police Atul Sharma, an official said. The decision came after three people were killed in Dhumanganj, one in Allahapur and a double murder took place in the Tharwai area of Allahabad on Sunday. “The Prayagraj SSP has been suspended,” Additional Chief Secretary (Home) Awanish Awasthi said.Akhilesh slams govt. Samajwadi Party chief Akhilesh Yadav has slammed the State government over the “deteriorating” law and order situation and said “Uttar Pradesh is becoming Hatya Pradesh”. “After the murder of a journalist and his brother in Saharanpur, six killings took place in the past 12 hours in Prayagraj (Allahabad). Due to deteriorating law and order, Uttar Pradesh is becoming ‘Hatya Pradesh’. Is this what the BJP wants UP to be identified as. When there’s no guarantee of people’s lives, then how can there be any development or faith,” he said in a tweet in Hindi. Earlier in the day, Mr. Sharma was transferred and attached to the DGP office while STF SSP Satyarth Anirudh Pankaj was made the new SSP of Allahabad.last_img read more

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first_imgIncessant rain triggered by a well-marked low pressure area over the Bay of Bengal threw normal life out of gear in several parts of Odisha on Thursday.The regional meteorological centre here issued red, orange and yellow warnings for the coastal and southern districts of the state till October 26.The state government declared the closure of all schools and Anganwadi centres for two days in eight districts and asked the teachers and staff to remain present at the institutes for an emergency.The district collectors of Cuttack, Ganjam, Gajapati, Bhadrak, Dhenkanal, Puri, Khordha and Jajpur declared holidays in all the schools and Anganwadi centres.East Coast Railway (ECoR) said incessant rain and subsequent water-logging on railway tracks affected the train services too.It said many express and passenger trains are running behind schedule while a few trains have been cancelled and rescheduled.The signalling posts also got affected at many stations due to heavy water flow all night long.While the Visakhapatnam-Brahmapur train has been cancelled from both directions, the Bhubaneswar-Visakhapatnam Intercity-Express will be terminated at Srikakulum which will run empty up to Visakhapatnam.The Visakhapatnam to Bhubaneswar Intercity-Express has been cancelled, said ECoR.However, Special Relief Commissioner (SRC) Pradeep Jena said chances of a flood situation in the state are low.“Over the last 24 hours, the distribution of rainfall has been even across the state so there is less likelihood of any flood situation in the state,” said Mr. Jena.The district collectors have been asked to remain alert to take all possible measures to meet the situation arising out of the heavy rain.“A mudslide has been reported from two villages of Badakalakot panchayat in Gumma block of Gajapati district in which 20 houses were destroyed, 80 villagers have been relocated and are being supplied with water and cooked food,” the SRC said.last_img read more

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first_imgLATEST STORIES WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding GINEBRA 98 – Slaughter 22, Brownlee 17, Tenorio 16, Devance 15, Aguilar 10, Ferrer 7, Caguioa 6, Thompson 4, Mercado 1.BLACKWATER 81 – Walker 26, Digregorio 12, Sumang 12, Pinto 8, Erram 6, Canaleta 6, Gamalinda 5, Marcelo 4, Sena 2, Belo 0.Quarters: 23-24, 45-48, 69-71, 98-81.ADVERTISEMENT Read Next MOST READ Ginebra trailed early and needed one big spurt in the fourth period to put the Elite away and extend the tournament’s longest winning streak to seven after opening up with a loss and remain at No. 1.“You don’t want to play San Miguel coming off a loss, you need to have high energy coming into that game to have a chance,” Cone went on, referring to their 6:45 p.m. clash with the powerhouse Beermen on Sunday which could ultimately mean No. 1 seeding for his Kings.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutBlackwater dropped to 4-5, losing for just the second time in six games since Henry Walker arrived. The Elite would need to sweep their remaining two games to advance to the quarterfinals outright.The scores: E.T. returns to earth, reunites with grown-up Elliott in new ad  Frontrow holds fun run to raise funds for young cancer patients  Trending Articles PLAY LIST 00:50Trending Articles01:19Fire erupts in Barangay Tatalon in Quezon City01:02Fajardo predicts there will be no sweep in PBA Finals01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Paul Desiderio embracing role as new UP skippercenter_img Nonong Araneta re-elected as PFF president LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary Don’t miss out on the latest news and information. Brace for potentially devastating typhoon approaching PH – NDRRMC BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight View comments Photo by Tristan Tamayo/INQUIRER.netWorking extra hard against an enemy that has made turns in the PBA Governors’ Cup, Barangay Ginebra on Friday night got the perfect reward for its effort and got ready for a bigger battle that’s just around the corner.“It was important to get this win because we turn around and play San Miguel Beer,” Ginebra coach Tim Cone said, minutes after rallying for a 98-81 decision of Blackwater, which the Gin Kings ground out the entire night at Mall of Asia Arena in Pasay. “The final score doesn’t give justice to the difficulty of this game.”ADVERTISEMENT Fire hits houses in Mandaluyong Citylast_img read more

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first_imgJosephine Medina. Photo by Randolph B. LeongsonWinning a bronze medal in the 2016 Rio Paralympics brings its own set of expectations.But Josephine Medina would rather shrug off the pressure and just focus on doing her best for the country in the upcoming 2017 ASEAN Para Games. ADVERTISEMENT End of the road for Ceres in AFC Cup BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight PH boxing team determined to deliver gold medals for PH PLAY LIST 05:25PH boxing team determined to deliver gold medals for PH00:59Sports venues to be ready in time for SEA Games01:27Filipino athletes get grand send-off ahead of SEA Games00:50Trending Articles01:35Panelo suggests discounted SEA Games tickets for students02:49World-class track facilities installed at NCC for SEA Games03:07PH billiards team upbeat about gold medal chances in SEA Games03:04Filipino athletes share their expectations for 2019 SEA Games00:45Onyok Velasco see bright future for PH boxing in Olympics02:25PH women’s volleyball team motivated to deliver in front of hometown crowd LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary Read Next Frontrow holds fun run to raise funds for young cancer patients  Currently, she is forced to train by herself or with her partner Pablo Catalan, who isn’t even getting any allowance from the governing body.“The issues with our incentives will always be present. Same on us not having a coach. We’re training without a coach while the other teams are training with experienced coaches. We’re already at a disadvantage. That’s why we can’t help on always asking ourselves if you really trained hard,” she said.Still, what keeps Medina from doing this is her will to make the Philippines proud.“Even if you don’t win, the important thing is that you fought a good fight in the games. You no longer think of yourself because you fight for your country,” she said.ADVERTISEMENT Fire hits houses in Mandaluyong City Brace for potentially devastating typhoon approaching PH – NDRRMCcenter_img “There’s too much pressure because they expect you to always win a medal. But for me, no matter what happens, I’m sure that I’ll always give my 100-percent in the games,” she said.Placing third in singles class 8 in the Rio Games, Medina is seen as one of the shoo-ins to deliver on table tennis’ target of two mints.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutBut the 47-year-old paddler doesn’t want to get too caught up on the promises, saying, “It’s hard to assure the medal. The approach should always be God’s will.”While the paraathletes are now enjoying some level of support from the government and other sponsors, Medina believes they are still not getting enough to let them train at a high level. Nonong Araneta re-elected as PFF president MOST READ WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding E.T. returns to earth, reunites with grown-up Elliott in new ad  LATEST STORIES Don’t miss out on the latest news and information. View commentslast_img read more